Samuel F. B. Morse was born in Charlestown, Massachusetts, the first child of the pastor Jedidiah Morse (1761–1826), who was also a geographer, and his wife Elizabeth Ann Finley Breese (1766–1828). His father was a great preacher of the Calvinist faith and supporter of the American Federalist party. He thought it helped preserve Puritan traditions (strict observance of Sabbath, among other things), and believed in the Federalist support of an alliance with Britain and a strong central government. Morse strongly believed in education within a Federalist framework, alongside the instillation of Calvinist virtues, morals and prayers for his first son.

Telegraph: As noted, in 1825 New York City had commissioned Morse to paint a portrait of Lafayette in Washington, DC. While Morse was painting, a horse messenger delivered a letter from his father that read, "Your dear wife is convalescent". The next day he received a letter from his father detailing his wife's sudden death. Morse immediately left Washington for his home at New Haven, leaving the portrait of Lafayette unfinished. By the time he arrived, his wife had already been buried. Heartbroken that for days he was unaware of his wife's failing health and her death, he decided to explore a means of rapid long distance communication.

Relays: Morse encountered the problem of getting a telegraphic signal to carry over more than a few hundred yards of wire. His breakthrough came from the insights of Professor Leonard Gale, who taught chemistry at New York University (he was a personal friend of Joseph Henry). With Gale's help, Morse introduced extra circuits or relays at frequent intervals, and was soon able to send a message through ten miles (16 km) of wire. This was the great breakthrough he had been seeking. Morse and Gale were soon joined by Alfred Vail, an enthusiastic young man with excellent skills, insights and money.